The Effect of Cycloheximide on Translocation and Incorporation of Leucine and Lysine in Duodenal Sacs 1

Summary

Cycloheximide (CHX) inhibits the incorporation of leucine and lysine into the proteins of the intestinal tract of rats regardless of whether the CHX is present in the incubation medium or whether it is given by injection to the animals prior to sacrifice. Translocation from mucosa to serosa is also inhibited when CHX is given by injection to the intact animal but when present in the medium it acts as a stimulant. Both amino acids appear more rapidly in serosal fluid and intestinal tissue in the presence of the inhibitor than in its absence.