Abstract
Summary
Available data on blood and tissue histamine in laboratory rodents do not give reliable information on “normal values” for histamine levels. To obtain this information, the fasting and postprandial histamine of blood, lung, liver, stomach, small and large intestine, was determined in mice, rats, hamsters, and guinea pigs under uniform experimental conditions, using a fluorometric method. The results were analyzed statistically. It was found that all four species studied differed from each other regarding the content of histamine in blood and certain tissues. The differences were most marked between mice and other rodents. There was no experimental evidence that feeding, after a prolonged fast, significantly affected the levels of blood or tissue histamine in the rodents studied.
The technical assistance of Mr. G. Chmura, Mrs. T. Hoogen, and Mrs. M. McCubbin, is gratefully acknowledged.
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