Further Evidence of Skeletal Response to Exogenous Ascorbic Acid 1

Summary

The response to ascorbic acid administration was studied using the young chick. Plasma acid phosphatase and ⁴⁵Ca activities (⁴⁵Ca previously incorporated by the skeletal system) were consistently and equally elevated following ascorbate injection. Each of these factors is indicative of bone resorptive activity. Since total plasma calcium was depressed by the ascorbate, it is suggested that the effect on the skeleton may have been indirect, however.