Possible Mechanism of Posttesticular Antifertility Action of 3-Chloro-1,2-propanediol 1

Summary

Oral administration of 3-chloro-1,2-propanediol (6.5-15 mg/kg daily) produces an antifertility effect in males without interfering with spermatogenesis or diminishing libido. With the lowest effective dose tested, 6.5 mg/kg daily, there is no histological evidence by 14 days which reveals a mechanism of action. With slightly higher doses, beginning with 9.5 mg/kg, peritubular edema, intratubular dilatation and increased tissue weights, beginning in the initial segment of the caput, suggests an interference with absorptive capacities of the epididymis.