Abstract
Summary
The administration of sulfobromophthalein (BSP) and indocyanine green (ICG) produced a decrease in bile flow, in the isolated perfused rat liver. A dose-related effect is shown for BSP while ICG, in equimolar concentrations, produced a more prolonged inhibitory effect on bile flow and rate of excretion. Possible mechanisms for the effect of these dyes on bile excretion are discussed.
The authors are grateful to Mrs. A. Harinasuta for technical assistance and to Dr. J. Penhos for advice.
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