The Influence of Dihydrostreptomycin upon Avillous Hyperplasia and Duodenal Ulceration in the Pantothenate-Deficient Mouse

Conclusions and Summary

Dihydrostreptomycin lowered the incidence of chronic duodenal ulcers in pantothenate-deficient mice. It also reduced the average size of a lesion, focal avillous hyperplasia, thought to be precursive. These findings raise the possibility that an organism may participate in the pathogenesis of both lesions, since lowering of resistance to infection is a well-documented effect of pantothenic acid deficiency (4), and in rats may be a major cause of death (5).