Influence of Angiotensin II on the Systemic and Pulmonary Circulations of Intact Anesthetized Dogs 1

Summary

Responses of the small pulmonary veins to systemic intravenous infusion of angiotensin II were measured directly in 15 intact anesthetized dogs. Systemic and pulmonary venous pressures were essentially unchanged. Change in pulmonary arterial pressure was not marked and probably due to action of angiotensin on the pulmonary arterial system. Systemic arterial pressure increased markedly while cardiac output decreased. Thus, angiotensin II in the doses used constricts precapillary systemic vessels but at the same time has little effect on the pulmonary and systemic veins and on the pulmonary arterial system.