Abstract
Summary
The ability of soterenol and isoproterenol to reduce endotoxin lethality in chick embryos and mice was compared. Soterenol was significantly more potent than isoproterenol at lower concentrations in both models. At higher concentrations (10 mg/kg in mice of 0.075 μg/egg) the difference between the drugs was not significant. The role of β-adrenergic stimulators in combating endotoxin lethality was discussed.
The authors wish to acknowledge the technical assistance of R. L. Stratman and the advice of K. W. Dungan.
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