Effect of Heparin on the Kinin-Forming Activity of Trypsin,Plasmin,and Various Kallikreins 1

Conclusion

The effect of heparin on the kinin-forming activity of trypsin, plasmin, and kallikrein from human plasma, dog salivary gland, and dog plasma was studied. Heparin at concentrations of 5 units/ml was a potent inhibitor of dog plasma kallikrein. This inhibitory activity was equivalent to 500 units of Trasylol or 0.1 mg soya bean trypsin inhibitor. At high concentrations (2000 units/ml), heparin inhibited 80% of human plasma kallikrein activity and 40% of dog salivary kallikrein activity. The kinin-forming activity of neither trypsin nor human plasmin was inhibited.