Abstract
Summary
The effects of nicotine on H+ secretion, transmucosal PD, and resistance were studied in isolated bullfrog gastric mucosa. It was found that nicotine produced a reversible dose-related inhibition of H+ secretion, with an increase in transmucosal PD, resistance, and calculated short-circuit current. The results indicate that nicotine may selectively inhibit H+ secretory mechanism.
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