Abstract
Summary
An emphysema-like change in rat lungs was produced in young animals by the chronic administration of papain for 4 weeks. Both aerosol and intratracheal administration produced lesions of equal severity. The aerosol method was quicker to administer, produced fewer fatalities and was more easily quantitated.
Aerosol papain treatment of rats may provide a means for studying the effect of drugs on an experimental emphysema condition.
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