Intra-arterial Injections of Histamine,Serotonin,or Bradykinin: A Topographic Study of Vascular Leakage 1

Summary

Histamine, serotonin, and bradykinin, injected intra-arterially, cause (in susceptible organs) vascular leakage predominantly from the venules. The vascular segments affected are the same as when the mediators are injected locally. This suggests that the selective response of the venules depends on an intrinsic property of the venular wall, and not on the route whereby the mediator reaches the vessel. In certain organs (brain, cerebellum, testis, Gasserian ganglion) histamine-type mediators are apparently unable to cause vascular leakage.