Abstract
Summary
Alterations in the uterine wet weight response to mestranol or norethynodrel were found to occur following pretreatment of immature rats with various drugs. Pretreatment with phenobarbital or SKF 525A was found to decrease and increase, respectively, the uterine wet weight in controls as well as in mestranol-treated groups. Of the other drugs tested, only tolbutamide increased uterine wet weights in both control and mestranol-treated groups. In addition, the response to mestranol was increased following pretreatment with p-aminosalicylic acid, chlorpromazine, and imipramine and decreased following diphenylhydantoin, phenylbutazone, or scopolamine pretreatment. The response to norethynodrel was decreased after pretreatment with phenobarbital or diphenylhydantoin and increased following SKF 525A pretreatment. The test system used in these experiments was sensitive to drugs acting by different mechanisms and therefore could prove useful in predicting interaction between drugs and steroids used in treating gynecologic problems.
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