Gluconeogenesis in Liver Slices from Partially Hepatectomized Rats 1

Summary

During the 24-hr period after 70% hepatectomy, rats kept without food were found to maintain blood glucose levels comparable to those of sham-operated controls. As indicated by measurements of L-alanine-¹⁴C and H¹⁴CO₃ incorporation into glucose and net glucose production, the rate of gluconeogenesis in liver slices was higher for the partially hepatectomized rats than for sham-operated controls. The enhanced gluconeogenesis exhibited by the residual tissue from the hepatectomized animals was not accompanied by increase in the activity of either glucose-6-phosphatase and fructose-1, 6-diphosphatase.