Effects of Boranes Upon Tissues of the Rat. III. Tissue Amino Acids in Rats on a Pyridoxine-Deficient Diet 1

Summary

Dietary pyridoxal deficiency causes extensive changes, mostly reductions, in the amino acid content of the liver and kidneys, and to a lesser extent, the brain and heart. Treatment of pyridoxal-deficient rats with intraperitoneal decaborane (20 mg/kg) tended to accentuate the changes induced by pyridoxal deficiency. The data support the suggestion that boron hydrides (borane) are effective inhibitors of pyridoxal-dependent enzyme systems in vivo. The data indicate that other enzyme systems are also inhibited by boron hydrides.