Abstract
Summary
An immunosuppressive antilymphocyte serum prolonged the survival of skin allografts and suppressed the systemic graft-versus-host reactivity of lymph node cells from treated mice. Those same lymph node cells, however, were highly reactive when tested in the skin of the X-irradiated hamster, and that reactivity was dependent, at least in part, upon the presence of viable, histoin-compatible cell populations. We conclude that cells from the ALS-treated mice react well in that local assay while showing suppressed reactivity in the systemic assays of immunocompetence.
Get full access to this article
View all access options for this article.