Abstract
Summary
The T-1 cell line, derived from the human kidney, responds to two active thyroxine analogs, dijodothyropropionic acid (DTP) and triiodothyroacetic acid (TTA), qualitatively paralleling findings made with other systems. Compared to thyroxine, DTP is about equivalent in stimulating cellular proliferation, but possesses only 0.1 its potency in augmenting colony formation by these T-1 cells; TTA is at least 10 times more potent. These observations extend the usefulness of the T-1 cell line as an in vitro model for characterizing the peripheral response to the iodinated thyroidal hormones.
Get full access to this article
View all access options for this article.