Abstract
Summary
Two experiments were conducted with young male albino rats to investigate the interrelationships between thyroxine, citrate metabolism, and renal calcification in magnesium deficiency. Magnesium deficiency decreased urinary citrate markedly, increased kidney calcification, had no effect on serum citrate, and raised kidney citrate. Thyroxine administration did not materially affect citrate excretion but did offset accumulation of calcium and citrate in the kidney tissue of magnesium-deficient animals. It is concluded that urinary citrate does not play a role in prevention of kidney calcification.
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