Abnormal Sodium Regulation in Rats Following Chronic Intermittent Exposure to Carbon Tetrachloride 1

Summary

Rats with nodular cirrhosis due to CCl₄ intoxication showed a higher net positive sodium balance than their age-matched controls during three metabolic balance studies, done 10, 16, and 40 weeks after initial exposure to CCl₄. Renal hemodynamics and Uosm max were not different between both groups. The data suggest that intermittent periods of sodium retention precede the development of ascites in rats with CCl₄-innduced cirrhosis of the liver and that these changes occur in the presence of intact glomerular and tubular renal function.