Abstract
Summary
These experiments were designed to test the hypothesis that veratridine given intravenously causes a diuresis which is mediated by a decrease in plasma ADH. The results demonstrate that plasma ADH is not reduced, but rather is temporarily increased following veratridine administration. It is difficult to say which of the diverse pharmacological effects of veratridine produces the increase in ADH.
Urine flow decreases immediately after veratridine is given and then tends to increase, but the increase was not significant statistically in the present experiments.
We are indebted to Mrs. Pamela Geer, Mrs. Mary Ann Hill, and Dr. George Saba for technical assistance.
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