Metabolism of the Nonhepatic Splanchnic Area in Baboons and the Effects of Endotoxin

Summary

Values of several parameters of lipid and carbohydrate metabolism were established in the NHSA of anesthetized baboons under normal conditions. The tissues in this area consistently remove FFA and glucose. About 20% of palmitic and oleic acids are extracted. Of the amount of palmitic acid taken up, 10% is oxidized. Eight percent of the total CO₂ produced by the NHSA can be accounted for by FFA oxidation.

The metabolic effects of E. coli endotoxin administration were studied in terms of alterations in metabolite concentrations systemically and in the NHSA. Arterial FFA levels, as well as the flux of palmitic and oleic acids decreased substantially >60 min after endotoxin administration. Arterial glucose concentrations decreased at >60 min, lactate concentrations increased significantly, AcAc/ β-OHB ratios decreased significantly, both at <60 min and >60 min following toxin injection. Metabolic changes in the NHSA were inconsistent.