Abstract
Summary
Mice which have been immunized against the isoantigens of allogenic bone marrow cells reject bone marrow cells from donors of the allogeneic strain that are injected after the administration of a lethal dose of whole-body X irradiation. Repopulation of the damaged hematopoietic tissues is therefore prevented. It has now been demonstrated that treatment with anti-lymphocyte serum or normal rabbit serum abrogates such immunity, as allogeneic bone marrow cells repopulate the medullary cavity of the femur in sensitized recipients treated with anti-lymphocyte serum or normal rabbit serum before being exposed to a lethal dose of whole-body X irradiation.
We are indebted to Mrs. V. Littlewood, Mrs. C. V. Briscoe, Mr. D. J. F. Steers and Mr. M. Ho for technical assistance and to Miss A. L. Harris for typing the manuscript.
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