Urinary Excretion of Biotin and Metabolites in the Rat 1

Summary

Approximately 95% of an ip dose of 0.5 mg/100 g body weight of [¹⁴C] biotin is excreted by the young, male rat within 24 hr; 84% is excreted within the first 3 hr. The rate and extent of excretion of bisnorbiotin is essentially the same. The more water-soluble tetranorbiotin, both d-and l-sulfoxides of biotin, and biotin sulfone are excreted even more rapidly, with 96-98% of the injected dose appearing in the urine within the first few hours.