In Vivo and in Vitro Effects of Synthetic Luteinizing Hormone-Releasing Hormone (LH-RH) Upon the Secretion of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) in Intact and Castrated,Fed and Starved Adult Male Rats 1

Summary

Serum LH concentrations increased significantly following the administration of synthetic LH-RH in vivo in both intact and castrated, normally fed and starved adult male rats. Synthetic LH-RH failed to affect the serum concentration of FSH in the same animals. In vitro, basal and LH-RH-induced secretion of LH and FSH from pituitaries donated by intact and castrated, fed and starved rats were similar. The data indicate that the pituitary of the starved adult male rat is as sensitive to the gonadotropin-releasing effects of synthetic LH-RH as is the pituitary of the normally fed rat both in vivo and in vitro.