The Bone Marrow Colony Stimulating Factor (CSF): Relation of Serum CSF to Urine CSF 1

Summary

C₅₇BL mouse urine CSF was found to be of lower molecular weight than normal or postendotoxin mouse serum CSF. In addition the fall in activity of postendotoxin serum CSF was found to be unaltered by bilateral nephrectomy. Because of these findings, a reevaluation of previous data was made. It was concluded that the kidney may play little or no part in the clearance of serum CSF. The origin of urinary CSF was not established.