Abstract
Summary
Rat bone marrow cells formed colonies in agar after stimulation by colony stimulating factor (CSF) obtained from endotoxin-injected rats.
Separation of rat agar colony forming cells (CFCs) was performed on a discontinuous bovine serum albumin density gradient (BSA). Cell fractions obtained between 26.5 and 29.0% BSA showed enrichment for rat agar colony forming cells when cultured with CSF. Although the cell separation has not been complete the present studies support the contention that a subpopulation of cells intermediate between small lymphocytes and “blast” cells and resembling “transitional cells” are responsible for the agar colonies produced.
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