Enhanced Binding of 3,5,3′-L-Triiodothyronine by Rat Kidney Microsomes After Acclimation to Cold 1 2

Summary

Whole-tissue binding of triiodothyronine was augmented in liver, kidney and skeletal muscle following adaptation of the rat to cold. The basis of the increased kidney binding of this hormone was increased binding to microsomes, the putative subcellular locus of hormonal deiodination. Cold induction of deiodinative sites in tissues is the suggested etiology of the increased deiodination of triiodothyronine in vivo after cold acclimation observed in previous studies.