Abstract
Summary
Ouabain (50 μg/kg) decreases the PD of the histamine-stimulated canine gastric mucosa in vivo. Calculated electrical resistance (PD/I) was not decreased, and the rate of acid secretion was unaltered by ouabain. These findings support the inference that ouabain inhibited active chloride transport to diminish PD. This inference was verified by in vitro experiments in which ouabain inhibited the net flux of chloride in the acid-bathed mucosal segment.
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