Effect of Aldosterone on Acetylation of Ribosomal Proteins in Outer and Inner Zones of Kidney

Summary

The role of acetylation of ribosomal proteins in the regulation of protein synthesis was investigated by examination of the effect of aldosterone injection into adrenalectomized rats on the in vivo incorporation of [³H] acetate into the ribosomal proteins of kidney cortex and medulla (outer and inner zones) separately. Incorporation of acetate into acetyl groups of the ribosomal proteins of adrenalectomized rats was highest in the cortex. Three and a half hours after aldosterone administration, acetate incorporation in the cortex was 60% lower and in the medullary zones 77–94% higher than in the saline injected controls. This decrease for the cortex, and a calculated 38% decrease for whole kidney, are negatively correlated with increased protein synthesis after hormone administration.