Abstract
Summary
The effects of PGF2α on electrophysiologic and mechanical parameters in electrically driven rat papillary muscles were studied. PGF2α (100 ng/ml) was found to reduce slightly the maximum rate of rise of the action potential while increasing the plateau amplitude and duration. The magnitude of the twitch and the maximum rate of tension development were augmented whereas time to peak tension was unchanged. At a lower concentration, PGF2α (10 ng/ml) produced similar results, but of reduced magnitude.
The results may be explained by hypothesizing that PGF2α acts upon ionic conductances possibly by augmenting the slow inward current in rat myocardium.
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