Enhanced Splenic ATPase Activity in Immunized Mic 1

Summary

The ATPase activity in spleens of mice immunized with sheep erythrocytes was examined. A maximal increase in ATPase activity was found at the time when peak numbers of specific antibody forming cells were evident in the mouse spleen, 4–5 days after immunization. A relationship was observed between antigen dose and the peak response of both antibody PFCs and ATPase activity. The Mg²⁺-ATPase activity was specifically enhanced, while no increase in Na⁺K⁺-ATPase activity was demonstrable. These results suggest that a relationship exists between Mg²⁺-ATPase activity and antibody formation in mouse spleens.