Abstract
Summary
Colestipol, a bile acid-sequestrant anion exchange resin, was given in doses of 15 g/day to 18 patients with familial hyperlipopro-teinemia, and its effect compared to seven patients with this disorder treated with placebo. No alterations in diet were made. The colestipol significantly lowered plasma cholesterol and phospholipid levels and produced little alteration in triglyceride concentration. The resin had good patient acceptability and appeared to be an effective addition to methods available for the treatment of hyperlipoproteinemia, particularly type II.
We are grateful to Lynn Schwarz for technical assistance and to Harriet Bresnick for assistance in preparation of the manuscript.
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