Alteration of Bone Marrow-Thymus Cell Synergism in Hereditary Asplenic and Adult Splenectomized Mice

Summary

The cooperation between bone marrow (B) and thymus (T) cells was markedly impaired in mice with congenital as-plenia. The deficiency of IgM producers could not be corrected by neonatal transplantation of spleen cells. The use of T and B cells from splenectomized donors results in a marked shift from 19S to 7S antibody forming cells.