Abstract
Summary
Clofibrate, nominally an anti-hyperlipemic agent, added to the diet for a week prior to the inoculation of rats with S. pneumoniae protected some of the rats from what would normally be a uniformly lethal infection. Plasma from clofibrate-treated rats was neither bactericidal nor bacteriostatic, yet drug-treated rats displayed significantly diminished incidence and extent of bacteremia. Clofibrate does not alter carbon clearance, thus it is unlikely that clofibrate affords protection through enhanced reticuloendothelial removal of microorganisms. The mechanism and implications of clofibrate protection remain to be determined.
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