Cardiovascular Responses to Three Prostaglandin Endoperoxide Analogs in the Dog 1

Summary

Three stable analogs of prosta-glandin endoperoxides have been studied in limited quantities for their effects on the canine cardiovascular system. They are potent systemic pressor agents and powerful pulmonary vasoconstrictors. They directly increase myocardial contractile force. These responses are not altered by indomethacin. In their blood pressure and myocardial effects they are considerably more potent than arachidonic acid and may be estimated to be more potent than the primary bisenoic PGs, PGE₂ and PGF₂₀. The cyclic ether endo-peroxide analogs of Bundy are approximately twice as potent in their effects on these parameters as the azo analog of Corey et al.