Experimental Hepatomas: Dehydrogenation of Reduced Pyridine Nucleotides by the D-T Diaphorase 1

Summary

Major differences were observed in the dehydrogenation of reduced pyridine nucleotides when experimental transplantable hepatomas were compared with livers of control animals and livers of tumor-bearing animals. The enzymatic activity of the D-T diaphorase was increased almost fivefold in the hepatomas. The same increase in enzymatic activity was observed in one slowly growing and one rapidly growing Morris hepatoma. The possible functional significance of these findings is discussed.