Modification of Cultured Rabbit Cells by Ultraviolet-Inactivated Noncytocidal Shope Fibroma Virus 1

Summary

When treated with uv radiation at dosages that abolished infectivity and prevented synthesis of detectable viral DNA or antigens, SFV remained able to modify the cultural behavior of DRK₃ cells and to make them susceptible to unrelated VSV. These cellular modifications were not induced, however, when the input SFV was excessively irradiated. The results suggest that a functional SFV genome is required to alter the DRK₃ cells and that early gene functions of SFV, before synthesis of viral DNA or major antigens, are involved in the modification process.