Abstract
Summary
Alterations in the splenic mi-crocirculation which accompany the suppression and recovery of CFU and ERC were studied in mice treated with Myleran and in polycythemic mice treated with Myleran and Ep. During the time of suppression of ERC by Myleran in nonpolycy-themic mice, blood flow was reduced significantly. Flow returned to normal during the time when repopulation of ERC was occurring but CFU was still suppressed. Administration of a split dose of Ep 3 days apart to polycythemic mice treated with Myleran resulted in dramatic increases in flow 24 hr after the first injection of Ep, with no increases in 59Fe incorporation in the blood. The microvascular response was nearly abolished by 48 hr after this injection. The second injection of Ep elicited limited increases in blood flow 24 hr later, accompanied by increases in 59Fe uptake. These results suggest that the effect of Ep on the splenic microvasculature is indirect and mediated by a vasoactive substance(s) released from replicating ERC following stimulation by Ep.
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