Suppression of Chemical (DEN) Carcinogenesis in SWR/J Mice by Goat Antibodies Against Endogenous Murine Leukemia Viruses 1

Summary

We pre- and posttreated SWR/ J mice given 90 mg/kg of DEN with goat anti RadLV and AT 124 IgGs and studied their effects on the induction and latency of lung tumors. The results of these experiments tend to indicate a role of MuLVs in the etiology of the chemically induced lung tumors of SWR/J mice. The rate of tumor occurrence was greatly reduced in IgG treated mice and their survival time was significantly prolonged over nontreated mice. These findings require consideration of both ecotropic and xenotropic virus classes or their structural protein as cofactors in the chemically induced lung carcinogenesis process. Similar conclusions were drawn previously by others in an in vitro chemical transformation system (5).