Abstract
Summary
Intraventricular injection of 5HT (4 and 20 μg) in unanesthetized, unrestrained male rats fitted with permanent intrajugular cannulas for withdrawal of blood samples caused a dose-related elevation of plasma GH levels. Similar effects were also observed following intraventricular injection of the serotonin receptor agonist, quipazine. The GH-releasing effect of both drugs was abolished by a serotonin receptor blocker, methysergide. It is concluded that activation of the central serotoninergic system stimulates GH secretion in the rat.
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