Response of the Host Vascular System to Immunocompetent Lymphocytes: Effect of Preimmunization of Donor or Host Animals 1

Summary

We have previously shown that immunocompetent lymphocytes can induce angiogenesis following intradermal inoculation into allogeneic or semi-allogeneic host animals. Experiments are described demonstrating that preimmunization of donor animals leads to a specific increase in angiogenesis-inducing capacity of effector spleen cells, while preimmunization of host animals results in a selective, specific reduction in lymphocyte-induced vascular changes.

The results are discussed in terms of the increasing evidence that lymphocyte-induced angiogenesis is mediated by soluble factors (lymphokines) released following lymphocyte activation.