Contraction of the Canine Basilar Artery following Linoleic,Arachidonic,13-Hydroperoxylinoleic,or 15-Hydroperoxyarachidonic Acid

Abstract

The contractile activity of linoleic acid (LA), arachidonic acid (AA), 13l-hydroperoxy-cis-9-trans-11-octadecadienoic acid (13HPLA), or 15l-hydroperoxy-cis-5-cis-8-cis-11-trans-13-eicosatetraenoic acid (15HPAA) was tested on canine basilar artery segments in a small chamber, using serotonin as the reference vasoconstrictor. The cumulative dose–response contraction was approximately 400 times that of serotonin. On the other hand, either 15HPAA or 13HPLA at 10^-6 M induced a contraction almost equal to the maximum attained with serotonin (1 × 10^-6 M) contraction. The maximal artery response to each of the hydroperoxy fatty acids was almost 1.4 times stronger than that obtained with serotonin, LA, or AA.