Oligoclonal IgG in the Cerebrospinal Fluid of Guinea Pigs with Experimental Allergic Encephalomyelitis

Abstract

Oligoclonal IgG bands were demonstrated in the cerebrospinal fluid of guinea pigs with experimental allergic encephalitis before clinical signs developed. No bands were found in the serum of these animals nor were bands found in the CSF or serum of control animals. Immunofixation techniques demonstrated that the bands were immunoglobulins of the γ G class.