Genetics of Xenotropic Virus Expression in Mice. II. Expression of Major Virus Structural Proteins in Crosses Involving NZB/BINJ,SWR/J,and 129/J Strains of Mice 1

Abstract

The expression of viral structural polypeptides and the production of infectious xenotropic virus were found to segregate together in NZB, 129/J, and SWR/J mice and in crosses between these strains. The viral p30 protein segregation pattern, as measured by competition radioimmunoassay using extracts of frozen spleens from backcross progeny, indicate that xenotropic murine leukemia virus expression is controlled by two dominant genes.