Abstract
Conclusions
Studies of the immunologic properties of native type II collagen in the past decade have delineated a new field in connective-tissue disease. The opinion that cartilage injury may not be merely the result of pannus but that the origin of synovial hyperplasia could, in some way, be related to cartilage is no longer iconoclastic. The recent advances in the field of collagen immunology have provided data which are clear cut, but the proper interpretation of the experimental results is, at present, only partially evident. In the near future, additional work may answer the questions posed in this review; out of controversy could come certainty.
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