Dopaminergic Mediation of the Diuretic and Natriuretic Action of Centrally Administered Rat Atrial Natriuretic Factor (99–126)

Abstract

Intracerebroventricular administration of either rat atrial natriuretic factor (99–126) or dopamine to conscious male hydrated rats resulted in an increase in urinaryvolume and sodium excretion. This activity was prevented, in both cases, by nonselective dopamine antagonist haloperidol (2.5 or 1.25 mg/kg sc, 18 and 2 hr before intracerebroventricular administration of atrial natriuretic factor). Our findings suggest that atrial natriuretic factor exerts its centrally mediated effects on sodium and water metabolism, at least in part, via a dopaminergic mechanism.