Abstract
When certain alkaloidal salts are added to defibrinated blood of the cat the bases can be extracted by shaking the blood with chloroform. Strychnin has been recovered in this way from a million parts of blood. The method is applicable to codein, heroin, and quinin, and almost certainly to nearly all the common vegetable alkaloids. Morphin is extracted less readily than most of the alkaloids.
About 20 per cent of an intravenous dose of codein was recovered from blood drawn immediately after the injection. Quinin was recovered from blood drawn at once after the intravenous injection in the cat, but very small amounts were present in the defibrinated blood.
Urine and bile may be extracted in the same way with slight modifications.
The defibrinated blood of the cat yields less than a milligramme (as a rule) of chloroform-soluble matter.
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