Action of Enzymes on Causative Agent of the Chicken Sarcoma

Summary

I. The causative agent of the Kous chicken sarcoma in the tumor fragments or in the cell-free tumor filtrate was inactivated by trypsin and pepsin, but was unaffected by the lipase, urease, or amylase preparations which were used as regards its capacity to produce tumor growth. 2. The causative agent was not destroyed if the proteolytic energy of trypsin and pepsin was abolished by heat inactivation. 3. Specificity of the proteolytic enzymes upon the causative agent of the chicken sarcoma suggests that the active agent is a protein or associated in sowe way with protein material.