“The relation of blood platelets to thrombus formation”

In the frog, rabbit and dog experimental thrombi three to ten minutes old were studied. In the youngest thrombi there was agglutination of blood platelets or spindle cells and agglutination of erythrocytes without evidence of fibrin formation. The fusing and distortion of the erythrocytes were marked. The erythrocytes were sometimes broken up into small granular masses which simulated blood plates. By the use of a sodium metaphosphate solution it was possible to distinguish the blood platelets from the degeneration products of the erythrocytes.