Abstract
Summary
The daily administration for periods of 2 to 6 months of a sheep anterior pituitary extract to female rats resulted in a marked atrophy of the ovaries after a preliminary increase in weight. This change was associated with an increase in the weight of the hypophysis and the appearance of many “castration cells” in the anterior lobe.
The continued daily injection of a gonadotropic preparation made from blood of pregnant women produced a marked increase in ovarian weight which was maintained for as long as one year. The hypophysis also showed a marked increase in weight which was associated with histologic changes affecting the chromophobes and eosinophilic cells.
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